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These drugs require medical supervision, including monitoring for side effects and periodic reassessment of weight goals

Unlike semaglutide, tirzepatide, and retatrutide (which are all peptide-based), orforglipron is a synthetic small molecule that binds to and activates the GLP-1 receptor

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Your appetite will stabilize

It binds to the GLP-1R, stimulating insulin secretion, suppressing glucagon release, delaying gastric emptying, and promoting satiety

Pancreatic safety of once-weekly dulaglutide in Chinese patients with type 2 diabetes mellitus: Subgroup analysis by potential influencing factors